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Edrophonium test in Eaton-Lambert syndrome

Quantitative oculography

Ocular Motor Neurophysiology Laboratory, Cleveland Veterans administration Medical Center; the Department of Neurology (Drs. Dell'Osso, Daroff, and Abel), Case Western Reserve University School of Medicine, Cleveland, OH; and the Department of Neurology (Dr. Ayyar), University of Miami School of Medicine, Cord Gables, FL.

Accurate ocular motility recordings were made of the saccadic responses of five patients with Eaton-Lambert syndrome (ELS). It was found that, contrary to common belief, the ocular motor system is affected. The saccades of ELS patients mimicked those of patients with myasthenia gravis (MG). Both groups exhibited hypometria and multiple, closely spaced saccades. Two patients demonstrated both saccadic facilitation and positive edrophonium tests. The ELS patients had slow or normal saccadic velocities, not the "super-fast" velocities found in patients with ocular MG.

Address correspondence and reprint requests to Dr. Dell'Osso, Ocular Motor Neurophysiology Lab (127A), Veterans Administration Medical Center, Cleveland, OH 44106.

Supported in part by the Vererans Administration.

Accepted for publication January 26, 1983.