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Divisions of Neurology and Neuropathology, the Vancouver General Hospital and The University of British Columbia, Vancouver, Canada.
Inclusion body myositis (IBM) is described in six elderly patients (three women) and in a young familial patient. They all showed the morphologically characteristic vacuoles containing osmiophilic membranous whorls and intracvtodasmic or intranuclear inclusions. There is a well-delineated bimodal age spectrum of IBM, with onset in the second and sixth decades, but otherwise the disorder seems to be a specific entky. Clinical, electrophysiologic, and morphologic features suggest a neurogenic origin in some cases.
Address correspondence and reprint requests to Dr. Eisen, Department of Diagnostic Neurophysiolugy (EMG), Vancouver General Hospital, 855 West 12th Avenue, Vancouver, Canada V5Z 1M9.
Presented in part at the Fifth International Congress on Neuromuscular Disease, Marseilles, France, September 1218, 1982.
Accepted for publication January 28, 1983.
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