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Department of Pediatrics, University of Alabama in Birmingham, School of Medicine, Birmingham, AL.
We treated 116 children with ACTH or prednisone. Fifty-two had infantile spasms with hypsarhythmia, and 64 had other types of intractable seizures. ACTH completely controlled seizures in all patients with infantile spasms and hypsarhythmia and 74% of those with other types of seizures. Prednisone controlled 51% of patients with infantile spasms and none with other seizures. Serious side effects were minimal for both drugs, and recurrent seizures occurred in 40 to 50% of patients within 4 to 14 months after completion of therapy.
Address correspondence and reprint requests to Dr. Snead, The Children's Hospital, 1600 7th Avenue South, Birmingham, AL 35233.
Supported in part by NINCDS Grant No. K07 NS 00484–03.
Accepted for publication November 24, 1982.
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