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NEUROLOGY 1983;33:1083
© 1983 American Academy of Neurology

Quantitative evaluation of the effects of L-dopa in torsion dystonia

A case report

Carol L. Richards, Paul J. Bédard, Gilles Fortin and Francine Malouin

École de réadaptation (Drs. Richards and Malouin) and Département d'Anatomie (Dr. Bédard), Université Laval, Département des Sciences Neurologiques (Drs. Bédard and Fortin) and Centre de recherche en Neurobiologie (Drs. Richards, Bédard, and Malouin), Hôpital de l'Enfant-Jésus 1401,18e Rue Québec, G1J 1Z4 Canada.

We used electrophysiologic methods in the diagnosis of torsion dystonia and the evaluation of therapy in a 7-year-old child. Electromyographic (EMG) activity patterns in five leg muscles were recorded during specific voluntary and passive movements as well as during gait. We found patterns of coactivation in leg muscles in walking or isolated movements, and a shortening reaction was seen in the tibialis anterior. These findings in combination with clinical observations led to the diagnosis of torsion dystonia and the choice of L-dopa therapy. Beneficial effects of therapy were assessed by the same methods.

Address correspondence and reprint requests to Dr. Richards, Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, 1401, 18e Rue Québec. G1J 1Z4, Canada.

Supported by the "Fonds de la Recherche en Santé du Québec" Chercheurboursier, Fonds de la Recherche en Santé du Québec (Dr. Bédard).

Accepted for publication December 12, 1982.






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