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NEUROLOGY 1983;33:1055
© 1983 American Academy of Neurology

Histochemical study of rectal aminergic nerves in type I familial amyloid polyneuropathy

Shu-ichi Ikeda, MD, Kimio Oguchi, MD, Shigeaki Kobayashi, MD, Shigeo Tsukahara, MD and Nobuo Yanagisawa, MD

Department of Medicine (Neurology) (Drs. Ikeda, Oguchi, and Yanagisawa) and the Department of Neurosurgery (Dr. Kobayashi), Shinshu University School of Medicine, Japan, and the Department of Ophthalmology (Dr. Tsukahara), Yamanashi Medical School, Yamanashi, Japan.

We found degeneration of aminergic nerves in nine patients with type I familial amyloid polyneuropathy by histochemical study of rectal mucosa obtained by biopsy. There was prominent degeneration of aminergic nerves in four patients with uncontrollable alternating constipation and diarrhea, but aminergic nerves were relatively preserved in two patients with intermittent constipation or diarrhea. Sympathetic denervation of the gastrointestinal tract was probably important in causing bowel symptoms.

Address correspondence and reprint requests to Dr. Ikeda, Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, 390, Japan.

Accepted for publication December 16, 1982




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S.-i. Ikeda, M. Nakazato, Y. Ando, and G. Sobue
Familial transthyretin-type amyloid polyneuropathy in Japan: Clinical and genetic heterogeneity
Neurology, April 9, 2002; 58(7): 1001 - 1007.
[Abstract] [Full Text] [PDF]


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