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NEUROLOGY 1983;33:1015
© 1983 American Academy of Neurology

The 20/20 eye in multiple sclerosis

Mark J. Kupersmith, MD, J. I. Nelson, PhD, William H. Seiple, PhD, Ronald E. Carr, MD and Penny A. Weiss

Departments of Ophthalmology and Neurology (Dr. Kupersmith) and the Department of Ophthalmology (Drs. Nelson, Seiple, Carr, and Ms. Weiss), New York University Medical Center, New York, NY.

Using clinical and electrophysiologic measures, we evaluated the visual pathway of patients who had multiple sclerosis, 20/20 Snellen acuity, and no history of optic neuritis. Delayed latencies were found in the transient visual evoked potentials (VEPs) of 38% of the patients, and interocular latency differences were abnormal in 67%. Contrast VEPs were abnormal in 4.6%. Psychophysical determinations of contrast sensitivity were abnormal in 78%. Only 17% of the patients had dyschrornatopsia, 36% had afferent pupillary abnormalities, and 59% had optic nerve pallor or nerve fiber layer loss. Psychophysical contrast evaluations and VEP studies were superior to other clinical evaluations in demonstrating visual dysfunction in these patients.

Address correspondence and reprint requests to Dr. Kupersmith, Department of Ophthalmology, New York University Medical Center, 550 First Avenue, New York. NY 10016.

This study was supported in part by Grants Nos. 02179 and 08142 from the National Eye Institute and by an unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness, Inc.

Presented in part at the Association for Research in Vision and Ophthalmology Annual Meeting, April 1982.

Accepted for publication December 14, 1982.




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