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NEUROLOGY 1983;33:943
© 1983 American Academy of Neurology

Olfactory impairment in Parkinson's disease

Christopher D. Ward, William A. Hess and Donald B. Calne

Experimental Therapeutics Branch, National Institute of Neurologic and Communicative Disorders and Stroke (Drs. Ward and Calne), and the Pharmacy Department, Clinical Center (Dr. Hess). National Institutes of Health, Bethesda, MD.

In comparison with closely matched controls, patients with Parkinson's disease had reduced scores in tests of odor detection and qualitative discrimination. Olfactory impairment was not related to age, duration of symptoms, treatment, intellectual function, or genetic factors and seemed to be a nonmotor manifestation of the disease.

Address correspondence to Dr. Ward, Oxford University Department of Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK.

Accepted for publication October 19, 1982.




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