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NEUROLOGY 1983;33:939
© 1983 American Academy of Neurology

Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins

Detection by ELISA

Eduardo Nobile-Orazio, Tom Vietorisz, Mary-Jo Messito, William H. Sherman and Norman Latov

Department of Neurology (Drs. Nobile-Orazio, Vietorisz, Messito, and Latov) and Medicine (Dr. Sherman), Columbia University, College of Physicians and Surgeons, New York, NY.

In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the "immunoblot" technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.

Address correspondence and reprint requests to Dr. Latov, Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032.

This work was supported by a grant from the Muscular Dystrophy Association and a Grant (No. NS 18016) from the National Institutes of Health. Dr. N. Latov is a recipient of Teacher-Investigator Development Award No. NS 00659. Dr. E. Nobile-Orazio is a visiting fellow in Neurology and is the recipient of the "De Visart" Award from the University of Milan, Italy.

Accepted for publication November 24, 1982.






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