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Effect of cholinergic agents in Huntington's disease

A reappraisal

Department of Neurology, Oregon Health Sciences University, Portland, OR.

The effects of centrally and peripherally active anti-cholinergic agents were investigated in four patients with Huntington's disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results, combined with previous studies, indicate that cholinergic agonists and antagonists that produce sedation may reduce chorea without improving coordination, and suggest that this antichoreic action is independent of their cholinergic actions.

Address correspondence and reprint requests to Dr. Nutt, Department of Neurology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201.

A preliminary report of this study was presented at the Experimental Therapeutics of Movement Disorders Symposium, May 1981.

Accepted for publication October 19, 1982.