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Geographic distribution of motor neuron disease and correlation with possible etiologic factors

Neuroepidemiology Section, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke (Drs. Bharucha, Schoenberg, and Raven), and Environmental Epidemiology Branch (Drs. Pickle and Mason). National Cancer Institute, and Biometry Branch (Dr. Byar), National Cancer Institute, National Institutes of Health, Bethesda, MD.

Average annual age-adjusted motor neuron disease (MND) mortality rates were mapped for the first time at the county level in the continental United States. Although the great majority of the rates for not differ significantly from the US average, the highest mortality rates were generally found west of the Mississippi and the lowest rates east of the Mississippi. MND mortality was associated with rural farming and socioenconomic status but not with urbanization, physician-population ratios, lead or mercury exposure, or mortality rates of five kinds of cancer.

Address correspondence and reprint requests to Dr. Schoenberg, NINCDS, NIH, Room 804, Federal Building, 7550 Wisconsin Ave., Bethesda, MD 20205.

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology, Washington, DC, April 1982

Accepted for publication October 10, 1982

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