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Can ethanol intoxication affect hernocoagulation to increase the risk of brain infarction in young adults?

Department of Neurology, the Second Department of Medicine, University of Helsinki, Helsinki, Finland.

we studied the effects of acute ethanol intoxication on platelet function, coagulation factors, and fibrinolytic activity in 12 healthy men. During the ethanol session, 10 of the 12 developed a transient decrease in fibrinolytic activity. Ethanol ingestion increased factor VIII coagulant activity, VIII-related antigen, and VIII-ristocetin cofactor. The highest levels were detected 16 hours after beginning ethanol ingestion (p <: 0.001), and the bleeding time decreased at 12 hours (p < 0.01). Ethanol had no effects on platelct count, beta-throm-boglobulin, antithrombin 111, ethanol gelation, or fibrinifibrinogen degradation products. Decreased fibrinolytic activity, increased factor VIII complex, and shortened bleeding time may explain why ethanol intoxication increases susceptibility to cerebral thrombosis.

Address correspondence and reprint requests to Dr. Kaste, Department of Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland.

This study was supported by the Finnish Foundation for Alcohol Studies, Finland.

Accepted for publication July 12, 1982.

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