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Glutamate or aspartate as a possible neurotransmitter of cerebral corticofugal fibers in the monkey

Department of Neurology, University of Michigan, Ann Arbor, MI.

We measured high affinity glutamate uptake in subcortical projection sites of monkey (Macaca fascicularis) 8 weeks after unilateral ablation of Brodmann's areas 4 and 6. Uptake decreased ipsilateral to the lesion in ventrolateral nucleus of thalamus, caudate nucleus, and pons. Uptake also decreased contralateral to the lesion in cervical and lumbar spinal cord. These results suggest that L-glutamate (or possibly L-aspartate) is a neurotransmitter of corticofugal fibers in primate.

Address correspondence and reprint requests to Dr. Young, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48109.

Supported by USPHS grants Nos. NS 15655, NS 00420, NS 00464, and NS 15140 and the United Cerebral Palsy Research and Educational Foundation (UCP R 291 and R 305).

Accepted for publication February 23, 1983.

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