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Pick's disease (lobar sclerosis)

Depletion of neurons in the nucleus basalis of Meynert

Departments of Neurology and Neuroscience (Drs. Uhl and Whitehouse), the Department of Neurology (or. Hilt), and the Neuropathology Laboratories of the Department of Pathology (or. Hedreen), and the Departments of Pathology and Neurology (Dr. Price), Johns Hopkins University School of Medicine, Baltimore, MD.

The nucleus basalis of Meynert (nbM) has been implicated in the pathogenesis of the presynaptic cholinergic deficiency in the cerebrum of patients with Alzheimer's disease. To further define the role of this cholinergic basal forebrain nucleus in dementia, we examined the nbM in two patients with lobar sclerosis, or Pick's disease (PD). The brains of both of these patients showed substantial reductions in the number of nerve cells in many neuronal populations, including the nbM. Our observations of the changes in the nbM are correlated with previous investigations of cholinergic markers in PD.

Address correspondence and reprint requests to Dr. Uhl, Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205.

This work was supported by Public Health Service grants NIH NS 10580, NS 15721, and NS 07179.

Accepted for publication March 11, 1983

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