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NEUROLOGY 1983;33:115
© 1983 American Academy of Neurology

Folate supplements and phenytoin-sa]licylate interaction

Fumio Inoue, MSc Pharm and Ronald J. Walsh, MD

Mental Health Drug & Medical Information Services (Mr. Inoue), and the Medical Services (Dr. Walsh), Ministry of Community and Social Services, Picton, Ontario, Canada.

We found biphasic fluctuations of serum phenytoin level when aspirin was added to chronic phenytoin therapy for an epileptic patient. The total serum phenytoin level was lowered initially by addition of aspirin. However, after 4 months on phenytoin-aspirin combination therapy, he showed elevated serum phenytoin levels, mild nystagmus, and serum folate deficiency.

Address correspondence and reprint requests to Mr. Inoue, Ministry of Health, Health Insurance Division, P.O. Box 68, Kingston, Ontario, K7L 5K1, Canada.

Accepted for publication May 13, 1982.






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