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Memory decline in the aged

Treatment with lecithin and physostigmine

Department of Neurology, University of Massachusetts Medical School, Worcester, MA.

Normal aged subjects were given lecithin and placebo for 5 weeks each in a double-blind crossover study. Supraspan tests of memory and learning failed to show any significant changes as a result of these treatments. Addition of a single IV infusion of physostigmine did not improve performance. These findings neither support nor weaken the "cholinergic hypothesis" of cognitive impairment in aging and dementia, but they imply that simple cholinergic hypofunction is unlikely.

Address correspondence and reprint requests to Dr. Drachman, Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01605.

Supported in part by BRSG Grant No. 6-324-72 and the Sterling Morton Research Fund.

Presented in part at the thirty-third annual meeting of the American Academy of Neurology, May 1, 1981, Toronto.

Accepted for publication February 24, 1982.

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