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Acrylamide induces early morphologic reorganization of the neuronal cell body

Department of Neurology, School of Medicine. SUNY at Stony Brook, Stony Brook, NY.

Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cytoplasmic reorganization with an outer mantle of Nissl and an inner perinuclear zone of pigmented bodies, and increased perineuronal cells. Distal axons showed little degeneration at this time. These findings suggest that the cell body plays an important role in the pathogenesis of dying-back neurotoxic disease, and that there may be direct toxic affect on the perikaryon itself.

Address correspondence and reprint requests to Dr. Sterman, Department of Neurology, School of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794.

This study was supported in part by Grant Nos. RR05736, MH-36856, and ES-02650.

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology, April 1982, Washington, DC.

Accepted for publication February 24, 1982.