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Circulating immune complexes in multiple sclerosis

Relation with disease activity

Division of Nephrology (Drs. Dasgupta, Johny and Dossetor) and Neurology (Dr. Warren), Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Two hundred fifty-four MS patients were studied for circulating immune complexes (CIO by three different assays: Raji-RIA, Clq-PEG, and Conglutinin-BA. Thirty-five percent of the sera were positive by one or more of these tests; Raji-RIA had the highest sensitivity (29.4%). Incidence of CIC in acute relapse, progressive, remission, and stable state of MS was 33.3%, 30.2%, 26.1%, and 23.1%, respectively, by Raji-RIA, compared with 7.75% and 8.82% among normal and neurologic controls. The incidence of CIC in neurologic controls differed significantly from both acute relapse and progressive disease, and almost significantly from patients in remission. There was no significant difference between patients with stable MS and neurologic controls, and there was no association of CIC with HLA-B7.

Address correspondence and reprint requests to Dr. Dasgupta, Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, T6G 2G3 Canada.

Accepted for publication January 20, 1982.

This research was supported by the Multiple Sclerosis Society of Canada; the G. and M. Muttart and the Richard E. Lee Foundations of Edmonton, Alberta; the Association of Canadian Travellers of Edmonton, Alberta; and the Friends of Multiple Sclerosis Research in Edmonton, Alberta.

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