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Cerebellar atrophy in epilepsy and headache

Lack of relationship to phenytoin

Departments of Neurology and Radiology, Medical College of Georgia, Augusta, GA.

CT scans of 70 patients with seizures and 48 patients with headaches were studied. Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself. We found no evidence that either phenytoin or epilepsy caused cerebellar atrophy.

Address correspondence and reprint requests to Dr. Green, Department of Psychiatry and Neurology, Tulane University School of Medicine, 1415 Tulane Avenue, New Orleans, LA 70112.

Supported in part by NINCDS contract 1 p50 NS 17007–01.

Accepted for publication December 10, 1981.