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Plasmapheresis decreases neuroelectric blocking activity in multiple sclerosis

Departments of Neurological Sciences, Physiology, and Hematology, and the Multiple Sclerosis Center, Rush University, Chicago, IL.

Serum neuroelectric blocking factor activity diminished after plasmapheresis in five of seven patients with MS but returned to baseline levels in 2 to 3 weeks. In the other two patients changes were insignificant. All patients studied had progressing symptoms. Five plasma exchanges of 2 liters were performed in 10 days. Two patients improved clinically, whereas five did not. There was no correlation between the level of neuroelectric blocking activity and changes in clinical status.

Address correspondence and reprint requests to Dr. Stefoski, 1753 West Congress Parkway, Rush-Presbyterian-St. Lukes Medical Center, Chicago, IL 60612.

Supported by National Multiple Sclerosis Society research grants No. RG 1230A1, by the Kroc Foundation, and by the E. V. Morris Multiple Sclerosis. Research Fund.

Presented in part at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 1980.

Accepted for publication December 22, 1981.