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Muscle acid protease activity in amyotrophic lateral sclerosis

Correlation with clinical and pathologic features

Departments of Neurology (Drs. Antel, Chelmicka-Schorr, Sportiello, Stefansson, and Arnason), and Pathology (Dr. Wollmann), University of Chicago, Pritzker School of Medicine, and the Surgery Brain Research Institute, Chicago, IL.

Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers, and the overall severity of disease.

Address correspondence and reprint requests to Dr. Antel, University of Chicago, Department of Neurology, 950 E. 59th Street, Chicago, IL 60637.

Supported by a grant from the Amyotrophic Lateral Sclerosis Foundation, Inc, New York, NY.

Accepted for publication December 15, 1981.

This article has been cited by other articles:

				H. Mitsumoto, M. R. Hanson, and D. A. Chad Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials Arch Neurol, February 1, 1988; 45(2): 189 - 202. [Abstract] [PDF]