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3-O-Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.

We studied in rats the effect of 3-O-methyldopa (OMD) on levodopa-induced rotations after unilateral destruction of the nigrostriatal pathway. Pretreatment of rats with OMD significantly reduced the number of rotations induced by levodopa, compared with the number of rotations obtained in the same rats with levodopa alone.

Address correspondence and reprint requests to Dr. Reches, Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032.

This work was supported in part by NIH grant NS15959–02, the Peggy Engl Fellowship awarded to Dr. Reches by the Parkinson's Disease Foundation, and by a Fogarty Public Health Service International Research Fellowship (NIH TW02884–01) awarded to Dr. Reches. Lynne R. Mielke was a Summer Student Fellow of the Parkinson's Disease Foundation.

Accepted for publication January 12, 1982.