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Metrizamide inhibits human brain hexokinase

Division of Neurology Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX.

The myelographic contrast agent, metrizamide, causes a temporary confusional state in many patients. Since metrizamide is a 2-deoxyglucose analogue, it was tested for inhibitory effects on glucose metabolism. The Michaelis constant (K_m) of human brain hexokinase for glucose rose from 0.039 to 0.24 and 0.47 mM with final metrizamide concentrations of 0, 16, and 32 mM, respectively. The maximal velocity did not change. Since metrizamide is injected into the human CSF in concentrations of up to 780 mM, impairment of brain glucose metabolism can be expected. These effects could be largely counteracted if metrizamide were injected in a 100 mM glucose solution.

Address correspondence and reprint requests to Dr. Bertoni, Division of Neurology Laboratory, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284.

This work was supported in part by grants from the State of Texas, the Veterans Administration, and NIH Grant No. ES02485. Dr. Bertoni is the recipient of a Teacher-Investigator Development Award (NINCDS K07 NS00555).

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology, Washington, DC, April 1982.

Accepted for publication January 12, 1982.

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