HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chou, S. M. Articles by Nonaka, I. Search for Related Content PubMed PubMed Citation Articles by Chou, S. M. Articles by Nonaka, I.

Involvement of the Onuf nucleus in Werdnig-Hoffmann disease

Department of Pathology (Drs. Chou and Kuzuhara), Cleveland Clinic Foundation, Cleveland, OH, and the Department of Pathology and Neurology (Dr. Nonaka), West Virginia University Medical Center, Morgantown, WV.

Contrary to contention that Onuf nucleus is spared in Werdnig-Hoffmann disease (WHD) as it is in ALS, we found central chromatolysis in the Onuf neurons of the sacral cord from all five WHD patients. They were less depopulated but the central chromatolysis appeared more frequently than in anterior motor neurons. In contrast, the sacral autonomic neurons were not affected in any of the five cases. This argues against the view that the Onuf nucleus is autonomic and is spared with other autonomic neurons.

Address correspondence and reprint requests to Dr. Chou, Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44106.

Accepted for publication January 12, 1982.

This article has been cited by other articles:

				P. S. Thomas Jr, G. S. Fraley, V. Damien, L. B. Woodke, F. Zapata, B. L. Sopher, S. R. Plymate, and A. R. La Spada Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy Hum. Mol. Genet., July 15, 2006; 15(14): 2225 - 2238. [Abstract] [Full Text] [PDF]