HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sears, E. S. Articles by Hayman, L. A. Search for Related Content PubMed PubMed Citation Articles by Sears, E. S. Articles by Hayman, L. A.

Maximizing the harvest of contrast enhancing lesions in multiple sclerosis

Department of Neurology (Drs. Sears, McCammon, and Bigelow), and the Department of Radiology (Dr. Hayman), University of Texas Medical School, Houston, TX.

Transient contrast enhancing lesions can be seen with CT in patients with MS, particularly during acute exacerbations. Conventional 40 gm iodine enhancement technique followed by immediate postinfusion scanning was compared with high dose (80 gm iodine) enhancement technique followed by a 1-hour delayed CT scan; delayed high dose technique (DHD) in nine exacerbations. New lesions, totaling 36 in all, were observed in each case with the DHD technique. With time, the borders expanded in 98% of lesions, thus confirming in vivo that a defective blood-brain barrier (BBB) underlies this phenomenon.

Address correspondence and reprint requests to Dr. Sears, Department of Neurology, University of Texas Medical School, 6431 Fannin, Houston, TX 77030.

Accepted for publication January 14, 1982.