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Local cerebral glucose utilization in the symptomatic thiamine-deficient rat

Increases in fornix and pyramidal tract

Department of Neurosciences, University of California at San Diego, La Jolla, CA.

Local cerebral glucose utilization (LCGU) was measured in asymptomatic rats on a thiamine (B₁)-dencient diet for 70 days and in symptomatic fats on a B₁-deficient diet for 98 days. LCGU increased in postcommissural fornix (F), pyramidal tracts (P), and inferior internal capsule (CAI) of symptomatic, compared with asymptomatic B₁-deficient rats but decreased in thalamic nuclei, auditory structures, and lesioned vestibular nuclei. B₁administration to symptomatic rats improved symptoms; decreased LCGU in F, P, and CAI; increased LCGU in the lesioned vestibular nuclei; but decreased LCGU in mammillary nuclei, anteroventral nucleus of thalamus, and medial raphe. The results indicate that B₁ deficiency symptoms correlate with LCGU changes in F and P and vestibular nuclei.

Address correspondence and reprint requests to: Dr. Sharp, Department of Neurosciences, Mail Code No. M024, UCSD School of Medicine, La Jolla, CA 92093.

This research was supported by NIMH Small Grant 1R03MH34257.

Accepted for publication January 19, 1982.

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