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Plasmapheresis in multiple sclerosis

Prospective trial of pheresis and immunosuppression versus immunosuppression alone

Neuromuscular Treatment Center, Department of Neurology, University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, TX.

A prospective trial of plasmapheresis and azathioprine or azathioprine alone was carried out on 20 patients with chronic progressive MS. Seven of 10 patients in each group continued therapy for 12 months. When the groups were compared by disability ratings, the combination of plasmapheresis and azathioprine was no better than azathioprine alone. Transient subjective improvement occasionally followed plasmapheresis, but no objective improvement was documented.

Address correspondence and reprint requests to Dr. Tindall, Department of Neurology, University of Texas Health Science Center at Dallas, Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75235.

This work was supported by the General Clinical Research Center of Southwestern Medical School, NIH grant, the Myasthenia Gravis Foundation Greater Dallas-Fort Worth Chapter, Muscular Dystrophy Association, and the Mabee Foundation.

Presented at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Canada, May 1981.

Accepted for publication November 18, 1981.

This article has been cited by other articles:

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