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NEUROLOGY 1982;32:725
© 1982 American Academy of Neurology

The pathogenesis of cryoglobulinemic neuropathy

David Chad, M.D., F.R.C.P. (C), Ken Pariser, M.D., Walter G. Bradley, D.M., F.R.C.P., Lester S. Adelman, M.D. and Vivian W. Pinn, M.D.

Departments of Neurology (Drs. Chad, Bradley, and Adelman), Medicine (Dr. Pariser), and Pathology (Drs. Adelman and Pinn), Tufts New England Medical Center, Boston, MA.

We describe a woman with vasculitic neuropathy and essential mixed cryoglobulinemia. Immunologically mediated demyelination and nerve ischemia, the latter either a result of vasa nervorum obstruction by cryoglobulins or secondary to vasa nervorum vasculitis, are the mechanisms most often associated with this neuropathy.

Address correspondence and reprint requests to Dr. Chad, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01605.

Accepted for publication November 18, 1981.




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