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Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy

Electrophysiologic studies on normal and demyelinated rat nerves

Neurophysiology Laboratory, Peripheral Nerve Center, Mayo Medical School and Foundation, Rochester, MN.

Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any electrophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.

Address correspondence and reprint requests to Dr. Low, Neurophysiology Laboratory, Peripheral Nerve Center, Mayo Medical School and Foundation, Rochester, MN 55905.

This investigation was supported in part by a Peripheral Neuropathy Center Grant from NINCDS (NS14304), a center Grant from MDA (12), and Mayo, Borchard, and Gallagher Funds.

Accepted for publication November 23, 1981.

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