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NEUROLOGY 1982;32:677
© 1982 American Academy of Neurology

Comparison of early and late naloxone treatment in experimental spinal injury

Alan I. Faden, M.D., Thomas P. Jacobs, B.A. and John W. Holaday, Ph.D.

Department of Neurology, Uniformed Services University of the Health Sciences (Dr. Faden and Mr. Jacobs), Bethesda, MD, and the Department of Medical Neurosciences (Dr. Holaday), Walter Reed Army Institute of Research, Washington, DC.

The effects of early (1 hour posttrauma) and late (4 hours posttrauma) naloxone treatment on neurologic recovery were compared after experimental cervical spinal injury. Neurologic scores did not differ significantly between the early and late naloxone-treatment groups, and both naloxone groups showed significantly better neurologic recovery than saline-treated controls during a 6-week follow-up. These findings confirm the therapeutic benefit of opiate antagonists in experimental spinal injury and indicate that even delayed naloxone treatment is effective in improving neurologic outcome.

Address correspondence and reprint requests to Dr. Faden, Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814

Accepted for publication October 16, 1981.




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A. I. Faden
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Arch Neurol, May 1, 1986; 43(5): 501 - 504.
[Abstract] [PDF]


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