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Calcium effect on generation and amplification of myokymic discharges

Department of Neurology, West Virginia University School of Medicine, Morgantown, WV.

Maneuvers designed to manipulate ionized calcium (Ca⁺⁺) were carried out in two patients with inflammatory polyradiculoneuropathy and myokymia. Increased clinical myokymia and myokymic burst amplification occurred when ionized Ca ⁺⁺ was lowered by plasma exchange or hyperventilation. Increasing ionized Ca⁺⁺ (by intravenous infusion of CaCl₂) decreased the myokymia. These findings indicate that myokymic discharges are altered by changes in serum ionized Ca⁺⁺ and effects on axonal excitability.

Address correspondence and reprint requests to Dr. Brick, Department of Neurology, West Virginia University School of Medicine, Morgantown, WV 26506.

Presented at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Canada, May 1981

Accepted for publication October 28, 1981.

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