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The electrodiagnostic distinctions between chronic familial and acquired demyelinative neuropathies

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA.

We compared the electrodiagnostic studies of 40 patients with chronic acquired demyelinative neuropathy and 18 patients with familial demyelinative neuropathy. Patients with acquired neuropathy had differential slowing of conduction velocity when distal latencies were compared with more proximal conduction velocities in the same nerve, when equivalent segments of different nerves were compared, and when dispersion of compound motor action potentials was examined. Conduction block was noted in some patients. Patients with familial disease had uniform conduction slowing of all nerve segments, and conduction block was not seen.

Address correspondence and reprint requests to Dr. Lewis, Department of Neurology, University of Connecticut Health Center, and Farmington. CT 06032.

Chronic acquired demyelinative neuropathy is characterized by multifocal slowing of nerve conduction, whereas familial demyelinative neuropathy is characterized by uniform conduction slowing.

Presented in part at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, April 1980.

Accepted for publication October 28, 1981.

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