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NEUROLOGY 1982;32:448
© 1982 American Academy of Neurology

Flexor and extensor postures in sedative drug-induced coma

David A. Greenberg, M.D., Ph.D. and Roger P. Simon, M.D.

Department of Neurology, University of California. San Francisco, CA.

Flexor and extensor postural reflexes are most commonly seen in coma after structural brain lesions, but may also occur in metabolic coma. We report 10 patients who exhibited flexor or extensor posturing as an early and transient feature of coma resulting from sedative drug ingestion. In comatose patients with normal pupillary reactivity but no ocular movements, these postural responses suggest sedative drug overdose.

Address correspondence and reprint requests to Dr. Simon, Neurology Service, 4M62, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110.

Dr. Simon is a recipient of a Teacher Investigator Award No. 1 K07NS00437-01.

Accepted for publication August 20, 1981.






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