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Intravenous glycerol and mannitol therapy in children with intracranial hypertension

Department of Pediatric Neurology, Minneapolis Clinic of Psychiatry and Neurology, and the Children's Health Center of Minneapolis and College of Pharmacy. University of Minnesota. Minneapolis. MN.

Acute intracranial hypertension may respond to intravenous mannitol, but frequent administration can cause cerebral edema or renal problems. We evaluated the use of 20% glycerol administered intravenously as an alternative to mannitol. Intravenous glycerol and mannitol were equally effective in lowering acute elevations of intracranial pressure. The duration of effect was similar for both agents. Side effects of intravenous glycerol were related to concentration, rate, and frequency of administration. In severe encephalopathies, such as Reye syndrome, we recommend infusions of 20% glycerol or 20% mannitol at a dose of 0.5-1.0 gm per kilogram. Glycerol should be administered in 0.45% or 0.9% saline, no faster than 1.5 ml (3.3 mOsm) per minute.

Address correspondence and reprint requests to Dr. MacDonald. 4225 Golden Valley Road, Minneapolis, MN 55422.

Accepted for publication September 2. 1981.