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Gamma-hydroxybutyrate in experimental myoclonus

Psychopharmacology Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA, and the department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA.

In Swiss mice, muscimol (3 mg per kilogram, intraperitoneally) caused myoclonic jerks of the hindquarters. These jerks were strong, repetitive, more or less regular, and of high frequency (peak response, 76 per minute). Pretreatment with sodium gamma-hydroxybutyrate (50 to 200 mg per kilogram) caused a dose-dependent blockade of these jerks. This drug also nullified an already developed muscimol response. All of the drugs currently being used in the management of postanoxic action myoclonus (Lance-Adams syndrome) block this response of muscimol. Gamma-hydroxybutyrate may be of value in the management of Lance-Adams syndrome and other forms of myoclonus.

Address correspondence and reprint requests to Dr. Menon. Psychopharmacology Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343.

This study was supported by the Veterans Administration.

Accepted for publication September 1, 1981.