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Freeze-fracture heterogeneity of the axolemma of premyelinated fibers in the CNS

Department of Neurology, Stanford University School of Medicine, and Veterans Administration Medical Center, Palo Alto, CA.

Freeze-fracture electronmicroscopy of developing optic nerve axons in rat demonstrated clusters of intramembranous particles on the external face in some fibers before myelination. These particle aggregates may represent precursors of nodes of Ranvier. The ability of the membranes of CNS fibers to develop regional specializations, which do not depend on the presence of either myelin or mature axoglial junctions, may be significant in terms of normal ontogenesis and membrane reorganization after demyelination.

Address correspondence and reprint requests to Dr. Waxman, Neurological Unit (127), Veterans Administration Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304.

This work was supported in part by the Medical Research Service, Veterans Administration, and by grants from the National Institutes of Health and the Kroc Foundation.

Accepted for publication September 17, 1981.

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