HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lawless, L. M. Articles by Muido, L. R. Search for Related Content PubMed PubMed Citation Articles by Lawless, L. M. Articles by Muido, L. R.

Protein binding of carbamazepine in epileptic patients

Pharmacy Services, Cambridge Hospital (Mr. Lawless), the Department of Pharmacy (Mr. DeMonaco). Massachusetts General Hospital. Boston, and Kennedy Hospital for Children (Dr. Muido). Brighton, MA.

The degree of protein binding of carbamazepine was evaluated in 45 mentally retarded epileptic patients. Although the mean percent unbound carbamazepine agreed with that obtained elsewhere, a wide interpatient variability was noted. There was a good correlation between unbound carbamazepine and total carbamazepine serum concentrations.

The results of this study indicate that the total carbamazepine serum concentration must be interpreted with caution, and the unbound fraction may be a more appropriate therapeutic measure.

Address correspondence and reprint requests to Mr. Lawless, Director of Pharmacy Services, Cambridge Hospital, 1493 Cambridge Street. Cambridge, MA 02138.

Accepted for publication September 18, 1981.

This article has been cited by other articles:

				O. A. Agbato, A. A. Elyas, P. N. Patsalos, E. M. Brett, and P. T. Lascelles Total and Free Serum Concentrations of Carbamazepine and Carbamazepine-10,11-Epoxide in Children With Epilepsy Arch Neurol, November 1, 1986; 43(11): 1111 - 1116. [Abstract] [PDF]