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The methylphenidate-induced stereotypy in the awake rat

Local cerebral metabolism

Department of Medicine, Division of Neurology (Drs. Bell, Alexander, and Schwartzman), and the Department of Physical Medicine and Rehabilitation (Dr. Yu), the University of Texas Health Science Center of San Antonio.

The local cerebral metabolic rate for glucose (1 = CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p 0.05) increases in 1-CMRg in globus pallidus, ventral lateral nucleus of the thalamus, subthalamic nucleus, red nucleus, substantia nigra, entopeduncular nucleus, inferior olivary nucleus, and the lateral cerebellar cortex. Significantly, 1-CMRg decreased in area 4 of the motor cortex. The auditory system showed no change in 1-CMRg, demonstrating the specific action of methylphenidate in the rat brain. This technique allows evaluation of the functional anatomy of the entire central nervous system and may be helpful in understanding the mechanisms of methylphenidate-induced stereotypy.

Address correspondence and reprint requests to Dr. Bell, Department of Medicine, Division of Neurology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284.

This work was sponsored in part by a grant from the American Parkinson's Disease Association. Dr. Bell is the recipient of N1H Tencher Investigator Award 5 K07 NS 00463-02.

Accepted for publication September 2, 1981.

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