HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mehta, P. D. Articles by Tourtellotte, W. W. Search for Related Content PubMed PubMed Citation Articles by Mehta, P. D. Articles by Tourtellotte, W. W.

Oligoclonal IgG bands in plaques from multiple sclerosis brains

New York State Institute for Basic Research in Mental Retardation. Staten Island, NY (Dr. Mehta and Ms. Miller) and the VA Wadsworth Hospital, Los Angeles, CA (Dr. Tourtellotte).

We studied oligoclonal IgG band patterns of individual unbound plaque extracts from seven autopsy MS brains by immunofixation after isoelectric focusing (IEF). The specimens showed 10 to 15 distant oligoclonal bands in pH region 7.0 to 9.3. Band profiles of different sections from the same MS brain were similar, implying that there is a common immunologic response. When residues from these brain sections, after thorough washing, were eluted at low pH, only three of seven showed low levels of IgG by enzyme-linked immunosorbent assay. When the IEF profiles of unbound arid bound IgG eluates from one brain were compared, two plaques showed similar profiles, whereas one had a different pattern. A plaque from two other brains showed band differences in the alkaline region of the gel. The data suggest that in some plaques there is a common immunologic response, but the response is different in others.

Address correspondence and reprint requests to Dr. Mehta. New York Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, NY 10314.

This investigation was supported wholly by Grant #RG-1180 from the National Multiple Sclerosis Society.

This study was presented in part at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Ontario. Canada. April 1981.

Accepted for publication September 2, 1981.

This article has been cited by other articles:

				D. Mcgavern, K. Asakura, and M. Rodriquez Do Antibodies Stimulate Myelin Repair in Multiple Sclerosis? Neuroscientist, January 1, 1999; 5(1): 19 - 28. [Abstract] [PDF]