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Lecithin is not effective in amyotrophic lateral sclerosis

Department of Neurology, Tufts-New England Medical Center. 171 Harrison Avenue, Boston, MA 02111.

Eleven patients with motor neuron disease (9 with amyotrophic lateral sclerosis, one with spinal muscular atrophy, and one with postpolio motor neuron disease) were treated with lecithin (55% phosphatidylcholine, 20 gm per day) for 3 to 12 months. Response was measured by quantitated muscle testing and functional evaluations of patients and untreated, matched controls. Lecithin therapy did not provide therapeutic benefit.

Address correspondence and reprint requests to Dr. Kelemen, Division of Neurology. Nassau County Medical Center, East Meadow, NY 11554.

This study was funded by a grant from the Muscular Dystrophy Association.

Accepted for publication August 4, 1981.

This article has been cited by other articles:

				H. Mitsumoto, M. R. Hanson, and D. A. Chad Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials Arch Neurol, February 1, 1988; 45(2): 189 - 202. [Abstract] [PDF]