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Low cerebrospinal fluid somatostatin in Parkinson disease

An irreversible abnormality

Erik Dupont, Stig Engkjær Christensen, Aage Prange Hansen, Bent de Fine Olivarius and Hans rskov

University Department of Neurology, Institute of Experimental Clinical Research and Second Clinic of Internal Medicine, Aarhus Kommunehospital, Aarhus, Denmark.

In 39 parkinsonian patients, CSF somatostatin content was 88.0 ± 4.1 pg per milliliter, which was about 40% less than in controls (147.3 ± 5.1 pg per milliliter). Somatostatin values were unrelated to age, sex, body weight, total CSF protein, immunoglobulin, or cell count in either group. Parkinsonian values were not related to duration of disease, severity, specific signs, or treatment. In contrast to multiple sclerosis, in which CSF somatostatin is low only during relapses, the low somatostatin content of CSF in Parkinson disease seems to be irreversible, to be present at the onset of symptoms, and to imply an irreparable functional or structural alteration of somatostatin-secreting neurons.

Address correspondence and reprint requests to Dr. Christensen, Second University Clinic of Internal Medicine, Aarhus Kommunehospital, DK 8000 Aarhus C, Denmark.

The study was supported by the Danish Medical Research Council and the Institute of Experimental Clinical Research, University of Aarhus.

Accepted for publication August 4, 1981.

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