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Neurologic manifestations of podophyllin toxicity

Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.

A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

Address correspondence and reprint requests to Dr. Lacy, Department of Neurology, Denver General Hospital, W. 8th Avenue and Cherokee Street, Denver, CO 80204.

Accepted for publication August 4, 1981.

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