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NEUROLOGY 1982;32:296
© 1982 American Academy of Neurology

Value of central nervous system IgG daily synthesis determination in the diagnosis of multiple sclerosis

Raul Mandler, M.D., Hershel Goren, M.D. and Rafael Valenzuela, M.D.

Departments of Neurology (Drs. Mandler and Goren) and Immunopathology (Dr Valenzuela), The Cleveland Clinic Foundation, Cleveland, OH.

Using laser beam immunonephelometry, we confirmed the value of Tourtellotte's formula in the diagnosis of MS. Moreover, since immunonephelometry presents several advantages, including simplicity, rapidity, and precision, it is a promising technique for the diagnosis of MS. Complicated measurements are not necessary. Determinations take only minutes. The results are reproducible. Mathematical manipulations are simple with readily available computers.

Address correspondence and reprint requests to Dr. Goren, Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44106.

Accepted for publication August 13, 1981.






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