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NEUROLOGY 1982;32:261
© 1982 American Academy of Neurology

Isotachophoresis quantitation of subtractions of multiple sclerosis intra-blood-brain barrier IgG synthesis modulated by ACTH and/or steroids

Wallace W. Tourtellotte, M.D., Ph.D., Alfred R. Potvin, Ph.D., Booe I. Ma, Ph.D., Robert W. Baumhefner, M.D., Michael J. Walsh, MB, B.Ch, Paul Dickstein, B.S., Timothy Ingram, B.S., Tina Cowan, B.S., Paul Shapshak, Ph.D. and Paul Delmotte, Ph.D.

Neurology Service (Dr. Tourtellotte, Messrs, Dickstein and Ingram, and Ms. Cowan), Neurology and Research Service (Drs. Ma, Baumhefner and Shapshak), VA Wadsworth Medical Center, and (Drs. Tourtellotte and Shapshak and Mr. Walsh) UCLA School of Medicine, Los Angeles, CA; Biomedical Engineering and Electrical Engineering (Dr. Potvin), the University of Texas at Arlington, Arlington, TX; and National Center for Multiple Sclerosis (Dr. Delmotte), Melsbroek, Belgium.

We combined the IgG is otachophoresis (ITP) method and a formula to quantitate IgG synthesis rate inside the blood-brain barrier (intra-BBB) in multiple sclerosis (MS) patients. In MS, most IgG synthesized was cathodic, but synthesis occurred in both anodic and cathodic regions. In addition, ACTH and/or steroids were found to reduce cathodic IgG synthesis more than anodic.

Address correspondence and reprint requests to Dr. Tourtellotte, Chief, Neurology Service, VA Wadsworth Medical Center, Wilshire and Sawtelle Boulevards, Los Angeles, CA 90073.

This research was supported in part by the VA Merit Research Funds, National Multiple Sclerosis Society, Kroc Foundation for Advancement of Medical Science, UTA Organized Research Funds, and Area VII M.S. Service League, Waterloo, IN.

Accepted for publication August 17, 1981.






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