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Neuropathology of progressive rubella panencephalitis after childhood rubella

Departments of Pathology (Drs. Townsend, Baringer, and McKerrow), and Neurology (Drs. Townsend, Stroop, Baringer, and Berg), University of California, San Francisco, and Veterans Administration Hospital, San Francisco, CA, and the Department of Neurology (Dr. Wolinsky), Johns Hopkins University, Baltimore, MD.

We studied neuropathologic, virologic, and immunobiologic aspects of a patient with acquired rubella developing progressive rubella panencephalitis. There were widespread white matter lesions with active vasculitis. Deposits of IgG were found in histologically normal cerebral vessels, and extracts of brain demonstrated large amounts of rubella-specific antibody. These studies suggest an immunologic component in this form of encephalitis.

Address correspondence and reprint requests to Dr. Townsend, Department of Pathology. HSW595, University of California Medical Center, Third and Parnassus, San Francisco, CA 94143.

Aided in part by a grant from the United Cerebral Palsy Research and Educational Foundation (J.S.W.). and grant NS07073 from the NINCDS, NIH (J.R.B.). J.S.W. is the recipient of a Research Career Development Award (NS00443) from the NINCDS.

Accepted for publication August 4, 1981.