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Significance of cortical disinhibition signs

Cornell University Medical College (Drs. Tweedy and Reding), New York, NY, Burke Rehabilitation Center (Drs. Tweedy, Reding, and Schulman, and Mr. Deutsch), White Plains, NY, Lisbon Medical School (Dr. Garcia), Hospital Santa Maria, Portugal, Department of Psychology, State University of New York (Dr. Schulman and Mr. Deutsch), Stony Brook, NY, and Westchester CTT Scan Associates (Dr. Antin), Bronxville, NY.

Several clinical signs traditionally associated with dementia were examined in a series of 103 patients referred to a dementia clinic. The snout and grasp reflexes were significantly correlated with impaired performance on cognitive tests, but not accentuated jaw-jerk, glabellar reflex, paratonia, suck, root, or palmomental reflexes. In general, the signs were more strongly correlated with CT evidence of ventricular dilation than with cortical atrophy. They seem to be related to supranuclear motor system dysfunction, and cannot be considered clinical markers of dementia.

Address correspondence and reprint requests to Dr. Tweedy, Burke Rehabilitation Center, 785 Mamaroneck Avenue, White Plains, NY 10605.

Accepted for publication July 2, 1981.

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