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Ethel Percy Andrus Gerontology Center and the Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles (Dr. Bondareff), and the Department of Psychiatry, University of Cambridge, Cambridge, U.K. (Drs. Mountjoy and Roth).
To examine the possibility that senile dementia may be associated with a loss of noradrenergic neurons that innervate the cerebral cortex, we used a Quantimet 720 image analyzer to estimate the number of neurons in the nucleus locus ceruleus in elderly patients with the clinical diagnosis of senile dementia. In all but one case, the diagnosis was established histopathologically as senile dementia of the Alzheimer type (SDAT). In a subgroup characterized by a high dementia score and relatively young age at death, there was a loss of about 80% of locus ceruleus neurons. This loss of neurons indicates a deficit of noradrenergic innervation to cerebral cortex in a group of patients which may represent a variant of SDAT.
Address correspondence and reprint requests to Dr. Bondareff, Ethel Percy Andrus Gerontology Center, University of Southern California, University Park, Los Angeles, CA 90007.
This study was supported by a Project Grant from the Medical Research Council. Dr. Bondareff was a Visiting Fellow of Clare Hall, University of Cambridge, on leave of absence from Northwestern University Medical School.
Accepted for publication July 2, 1981.
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