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Epilepsy Branch (Drs. Sato, White, Penry, and Kupferberg), National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD, and Department of Neurology (Drs. Dreifuss and Sackellares), University of Virginia Medical Center, Charlottesville, VA.
Valproic acid (VPA) and ethosuximide (ESM) were compared in a double-blind, response- conditional crossover study of absence seizures in 16 naive (previously untreated for absence seizures) and 29 refractory patients (18 male and 27 female; 4 to 18 years of age). In the naive patients VPA was as effective as ESM in reducing generalized spike-wave discharges on the telemetered EEG. Adverse reactions to VPA or ESM were generally mild and responded to withdrawal or dosage reduction of the drug.
Address correspondence and reprint requests to Dr. Sato, Epilepsy Branch. Federal Building, Room 114, National Institutes of Health. Bethesda, MD 20205.
This work was supported by contract NO1-NS9-2196 from the NINCDS.
Presented at the thirty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1979.
Accepted for publication July 2, 1981.
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