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Quantitative autoradiography of neurotransmitter receptors in Huntington disease

Department of Neurology, University of Michigan, Ann Arbor, MI.

We studied gamma-aminobutyric acid (GABA), benzodiazepine, and muscarinic cholinergic receptor-binding by quantitative autoradiography. In coronal sections from the brain of a patient with Huntington disease, binding for all three receptors in caudate and putamen was lower than control values. Binding to GABA and benzodiazepine receptors was increased in lateral and medial pallidum and decreased in ventrolateral thalamus. Muscarinic cholinergic receptors were markedly decreased in pallidum but not thalamus. The findings suggest that loss of striatal afferents to both segments of pallidum results in GABA and benzodiazepine receptor supersensitivity, and support the utility of quantitative autoradiography for receptor studies in human postmortem material.

Address correspondence and reprint requests to Dr. Penney, Neuroscience Laboratory Building, 1103 East Huron Street, Ann Arbor, MI 48109.

Accepted for publication May 13, 1982.

This article has been cited by other articles:

				J.-H. J. Cha, C. M. Kosinski, J. A. Kerner, S. A. Alsdorf, L. Mangiarini, S. W. Davies, J. B. Penney, G. P. Bates, and A. B. Young Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene PNAS, May 26, 1998; 95(11): 6480 - 6485. [Abstract] [Full Text] [PDF]

				A. Young, J. Greenamyre, Z Hollingsworth, R Albin, C D'Amato, I Shoulson, and J. Penney NMDA receptor losses in putamen from patients with Huntington's disease Science, August 19, 1988; 241(4868): 981 - 983. [Abstract] [PDF]