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Pergolide-induced circling in rats with 6-hydroxydopamine lesions in the nigrostriatal pathway

Mollie and Jerome Levine Neuroscience Research Laboratory, Department of Neurology, Rutgers Medical School, the University of Medicine and Dentistry of New Jersey, Piscataway, NJ.

In rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal system we compared the behavioral effects of pergolide with those of L-dopa, bromocriptine, and lergotrile. In this animal model of parkinsonism, doses of 0.25 mg per kilogram pergolide (free base) induced vigorous circling for 24 hours. Pergolide was more potent than bromocriptine or lergotrile. Pretreatment with alpha-methylparatyrosine nearly abolished the effects of bromocriptine, markedly diminished the effects of lergotrile, and only partially diminished the effects of pergolide. These findings suggest that pergolide should be more effective than bromocriptine in the treatment of parkinsonism.

Address correspondence and reprint requests to Dr. Duvoisin, Department of Neurology, UMDNJ-Rutgers Medical School, P.O. Box 101, Piscataway, NJ 08854.

Accepted for publication May 13, 1982.