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Characterization of ß-adrenergic receptors on human cerebral microvessels

Department of Pharmacology and Pharmacognosy (Drs. Ko- bayashi, Spano, and Trabucchi) and the Department of Neurology, (Drs. Frattola and Ferrarese) University of Milan, Milan, Italy.

Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific ß-adrenergic antagonist, (¹²⁵I) iodohydroxy- benzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific ß-adrenergic receptor sites in human cerebral microvessels supports the hypothesis of adrenergic regulation of the function of cerebral microvessels.

Address correspondence and reprint requests to Dr. Trabucchi, Department of Pharmacology, and Pharmacognosy, University of Milan, Via A. Del Sarto 21, 20129 Milano, Italy.

Accepted for publication May 13, 1982.

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